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目的:利用功能磁共振成像技术研究正常人及单侧长期感音神经性聋患者调幅音刺激任务时听觉皮层的激活,探讨单侧长期感音神经性聋患者听觉皮层优势半球的变化及可能存在的功能重组。方法:对11例健康受试者及21例单侧长期重度感音神经性聋患者分别进行正弦调幅音任务下的功能磁共振扫描,实验刺激声音为500 Hz的载波频率,8 Hz的正弦调幅音。正常对照组分别左、右耳呈现;耳聋组于健耳呈现。采用事件相关Sparse设计采集数据以减少扫描噪音,运用SPM2软件对数据进行统计学分析,得到脑功能活动的图像。结果:正常人组单耳刺激时,对侧听觉皮层激活容积及激活强度均明显大于同侧,表现为明显的对侧半球优势;耳聋组健耳刺激时,双侧听觉皮层均有激活,但仍为对侧优势。结论:听觉中枢具有可塑性,单侧感音神经性聋患者听觉皮层存在着结构重组。
Objective: To study the activation of auditory cortex during AMR task in normal subjects and unilateral long-term sensorineural hearing-impaired patients by using functional magnetic resonance imaging and to explore the possible changes in the predominant hemisphere of auditory cortex in patients with unilateral long-term sensorineural hearing loss Functional reorganization. Methods: Eleven healthy subjects and 21 patients with unilateral long-term severe sensorineural hearing loss underwent a sinusoidal amplitude modulation task under the task of functional magnetic resonance imaging, the experimental stimulus sound frequency of 500 Hz carrier frequency, 8 Hz sinusoidal amplitude modulation sound. The normal control group were left and right ears were presented; deafness group presented in the healthy ears. The event-related Sparse design was used to collect data to reduce the scanning noise. Statistical analysis of the data was performed using SPM2 software to obtain images of brain function activity. Results: In the normal group, the contralateral auditory cortex activation volume and activation intensity were significantly greater than those on the ipsilateral hemisphere, which showed obvious contralateral hemispheric dominance. In deafness group, both auditory cortex activated, Still contralateral advantage. Conclusion: The auditory center has plasticity. There is structural reorganization in the auditory cortex of patients with unilateral sensorineural hearing loss.