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目的了解多发性骨髓瘤（multiplemyeloma，MM）中瘤细胞凋亡与增殖之间的关系及最终造成浆细胞数目异常增多，形成MM的发病机制。方法运用末端脱氧核着酸转移酶介导的脱氧尿毒三磷酸缺口末端标记（TUNEL）技术，结合HE形态和免疫组化结果，半定量分析12例MM中瘤细胞的凋亡与增殖的情况。结并MM瘤细胞增殖水平低，凋亡水平也低于常见人类肿瘤的平均凋亡水平，在瘤细胞聚积成给节或弥漫浸润时，给节中无TUNEL阳性标记细胞，瘤细胞的凋亡与增殖之间呈正相关（P＜0.05）。结论在MM中，造成瘤细胞数量异常增多形成肿瘤的重要原因是凋亡的减少。
Objective To understand the relationship between tumor cell apoptosis and multiplication in multiple myeloma (MM) and finally the abnormal increase of plasma cell number and the pathogenesis of MM. Methods TUNEL technique mediated by terminal deoxynucleotidyl transferase-mediated deoxynivalenol triphosphate (TUNEL) was used to semi-quantitatively analyze the apoptosis and proliferation of tumor cells in MM in combination with HE morphology and immunohistochemistry. Conclusions The proliferation of MM cells is low and the apoptosis level is also lower than that of common human tumors. When tumor cells accumulate into nodes or diffuse infiltration, no TUNEL-positive labeled cells and apoptosis of tumor cells And proliferation was positively correlated (P <0.05). Conclusion In MM, the number of tumor cells is abnormally increased. The important reason for tumor formation is the decrease of apoptosis.