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骨髓移植后肝功能异常多归因于移植体抗宿主病(GVHD)。作者对骨髓移植前后肝功能作了回顾性研究,以观察GVHD与其他一些致肝病因素诸如肝炎史、化疗、放疗、感染以及治疗GVHD药物之间的关系,希望找到能预示移植后生存期和肝病发生的指标。方法:在Royal Marsden Unit连续做43例骨髓移植,其中再生障碍性贫血14例、急性白血病27例、其他恶性肿瘤2例。除3例由孪生兄弟供给外其余均接受HLA相同家属的同种骨髓。按Seattle方案进行,即移植前5天供者的白细胞层给肿瘤受者,随后2天给
Abnormalities in liver function following bone marrow transplantation are mostly due to graft versus host disease (GVHD). The authors made a retrospective study of liver function before and after bone marrow transplantation in order to observe the relationship between GVHD and other liver disease factors such as history of hepatitis, chemotherapy, radiotherapy, infection and the treatment of GVHD drugs. We hope to find out the prognosis of graft survival and liver disease Occurrence of the indicator. Methods: A total of 43 cases of bone marrow transplantation were performed in the Royal Marsden Unit, including 14 cases of aplastic anemia, 27 cases of acute leukemia and 2 cases of other malignant tumors. All but three of the same-donor, same-family bone marrow recipients except the three were provided by the twin brother. According to the Seattle protocol, the donor’s leukocyte layer was given to the tumor recipient 5 days prior to transplantation, followed by 2 days