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目的探讨2型糖尿病(T2DM)患者经胰岛素强化治疗后发生低血糖的原因。方法选取2012年9月至2014年9月2型糖尿病(T2DM)患者188例,动态监测患者血糖浓度,分析低血糖与患者并发症、年龄及对T2DM知晓程度的关系。结果并发症数量为0、1的患者低血糖发生率显著低于并发症数量≥2的患者(P<0.05),且并发症数量≥3的患者低血糖发生率显著高于无并发症患者(P<0.01);年龄≥70岁的患者低血糖发生率显著高于年龄41~50岁的患者(P<0.01);患者对T2DM相关知识掌握程度越高,低血糖发生率越低(P<0.05)。结论 T2DM患者胰岛素强化治疗后发生低血糖与患者并发症、年龄、T2DM知识知晓程度等因素相关,用药时应注意个体特殊性,积极预防低血糖。
Objective To investigate the causes of hypoglycemia after intensive insulin therapy in patients with type 2 diabetes mellitus (T2DM). Methods A total of 188 patients with type 2 diabetes mellitus (T2DM) from September 2012 to September 2014 were selected to monitor the blood glucose level dynamically. The relationship between hypoglycemia and patient’s complication, age and the degree of T2DM were analyzed. Results The incidence of hypoglycemia in patients with complication of 0 and 1 was significantly lower than that of patients with complication ≥ 2 (P <0.05), and the incidence of hypoglycemia in patients with complication ≥ 3 was significantly higher than that of patients without complication P <0.01). The incidence of hypoglycemia was significantly higher in patients over 70 years of age than in those between 41 and 50 years of age (P <0.01). The higher the degree of knowledge about T2DM, the lower the incidence of hypoglycemia (P < 0.05). Conclusions The incidence of hypoglycemia after intensive insulin therapy in T2DM patients is related to the complication, age, knowledge of T2DM and other factors. Individuals should pay attention to the particularity of individuals and prevent hypoglycemia.