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目的探讨不同品质浓香型白酒致SD大鼠肝脏损伤差异。方法 55只雄性SD大鼠随机分为:酒样①组、酒样②组、48v/v酒精对照组以及空白对照组,以慢性酒精性肝病大鼠模型建立方式灌胃30 d后处死实验动物,检测血清中氧化指标超氧化物歧化酶SOD、丙二醛MDA;肝功能指标谷丙转氨酶ALT、谷草转氨酶AST、谷氨酰转肽酶GGT;血脂指标甘油三酯TG、高密度脂蛋白HDL-C、胆固醇CHOL;并制作病理学切片,用SPSS16.0对结果进行统计学分析。结果连续灌胃30 d后,各指标均出现明显差异,与①号酒样组相比,②号酒样组的SOD降低(P<0.05)、MDA(P<0.01);ALT、AST、GGT均升高(P<0.05);HDL-C、CHOL升高(P<0.05);饮酒组较空白对照组相比,肝脏系数、TG饮酒组均升高(P<0.05),从病理切片来看,②号酒样组比①号酒样组的病变程度更严重。结论30 d灌胃后②号酒样对肝脏的损害大于①号酒样,提示不同品质白酒致肝脏损伤存在差异。
Objective To investigate the differences of hepatic injury induced by different quality Luzhou-flavor liquor in SD rats. Methods Fifty-five male Sprague-Dawley rats were randomly divided into three groups: wine sample ① group, wine sample ② group, 48v / v alcohol control group and blank control group. Rats were sacrificed after 30 days of chronic alcoholic liver disease , Serum SOD, MDA and malondialdehyde MDA; ALT, AST, GGT; triglyceride TG, high density lipoprotein HDL -C, Cholesterol CHOL; and making pathological sections, using SPSS16.0 for statistical analysis of the results. Results After 30 days of continuous gavage, there was a significant difference between the two groups. Compared with the model wine, the SOD in the wine-like group was lower (P <0.05) and MDA (P <0.01) (P <0.05). Compared with the blank control group, the liver coefficient and the TG drinking group were significantly increased (P <0.05), and from the pathological section See, ② number of wine samples than the number of wine-like group of more serious lesions. Conclusion After 30 days of gavage, the number of wine samples on the liver damage than the number of wine samples, suggesting that different quality liquor caused liver damage differences.