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目的探讨心血管疾病患者炎症因子超敏C-反应蛋白(hs-CRP)与摄氧效率斜率(OUES)的相关性。方法选择经皮冠状动脉介入治疗后患者17例,稳定型心绞痛21例,原发性高血压24例。采用症状限制性标准Bruce分级平板运动方案,同时测定摄氧量(VO2)、每分通气量(VE)。采用对数曲线拟合的方法 ,建立回归方程:VO2=a×lgVE+b,计算a为OUES值。应用全自动免疫散射比浊法检测血清hs-CRP。超声心动图测定左心室射血分数(LVEF)。结果血清lg(hs-CRP)与OUES75(r=-0.506,P<0.001)、OUES100(r=-0.567,P<0.001)、LVEF(r=-0.286,P<0.01)呈负相关。多元逐步回归分析显示,lg(hs-CRP)(β=-0.374,P=0.006)、身高(β=-1.854,P=0.036)、体重(β=-5.033,P=0.034)是OUES75降低的危险因素;lg(hs-CRP)(β=-0.396,P=0.003)、身高(β=-2.157,P=0.013)、体重(β=-5.912,P=0.011)是OUES100降低的危险因素。结论血清hs-CRP可能是反映心肺储备功能及左室收缩功能的有效标记物。
Objective To investigate the correlation between hs-CRP and OUES in patients with cardiovascular diseases. Methods 17 cases of patients after percutaneous coronary intervention, stable angina pectoris 21 cases, 24 cases of essential hypertension. Symptom limitation Bruce stratified exercise plan was used to measure the oxygen uptake (VO2) and ventilation volume (VE). Logarithm curve fitting method was used to establish regression equation: VO2 = a × lgVE + b, calculate a as OUES value. Serum hs-CRP was detected by automatic immunostaining turbidimetry. Echocardiography was used to measure left ventricular ejection fraction (LVEF). Results The serum hs-CRP was negatively correlated with OUES75 (r = -0.506, P <0.001), OUES100 (r = -0.567, P <0.001) and LVEF (r = -0.286, P <0.01). Multivariate stepwise regression analysis showed that the values of hs-CRP (β = -0.374, P = 0.006), height (β = -1.854, P = 0.036) and weight (β = -5.033, P = 0.034) The risk factors for the reduction of the risk of OUES100 were as follows: risk factors; hs-CRP (β = -0.396, P = 0.003), height (β = -2.157, P = 0.013) and body weight (β = -5.912, P = 0.011) Conclusion Serum hs-CRP may be a valid marker of cardiopulmonary reserve and left ventricular systolic function.