近4年来,对重组α干扰素进行了广泛的Ⅰ期和Ⅱ期临床试验,表明它对许多类型的白血病和淋巴瘤有作用。在注射最初几剂时,常可发生急性毒性作用(发热、寒战、肌痛和头痛等),但乏力和厌食的症状常可持续存在,并进而加重,此时就需要减少剂量,甚至停药。 In the past four years, a wide range of Phase I and Phase II clinical trials of recombinant interferon alpha have been shown to have an effect on many types of leukemias and lymphomas. Acute toxicity (fever, chills, myalgia and headache, etc.) can often occur during the first few doses of the injection, but the symptoms of fatigue and anorexia can often persist and further aggravate, at which time dose reduction or even withdrawal is required .