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目的探讨氟西汀对维持性血液透析(MHD)并抑郁症患者血压的影响。方法选取2010年5月—2012年5月保定市第三中心医院收治的MHD并抑郁症患者60例,随机分为对照组与治疗组,各30例。对照组患者予以一般降压药物治疗,治疗组患者在对照组基础上加用氟西汀治疗。观察两组患者治疗前后汉密尔顿抑郁量表(HAMD)评分、血压(收缩压、舒张压)变化情况及临床疗效。结果治疗前两组患者HAMD评分比较,差异无统计学意义(P>0.05),治疗后治疗组患者HAMD评分低于对照组,差异有统计学意义(P<0.05);治疗组患者治疗后HAMD评分低于治疗前,差异有统计学意义(P<0.05);治疗前两组患者收缩压、舒张压比较,差异无统计学意义(P>0.05),治疗后治疗组患者收缩压、舒张压低于对照组,差异有统计学意义(P<0.05);治疗组患者总有效率高于对照组,差异有统计学意义(P<0.05)。结论氟西汀治疗MHD并抑郁症患者的降压效果显著,可改善患者抑郁状况。
Objective To investigate the effect of fluoxetine on blood pressure in patients with maintenance hemodialysis (MHD) and depression. Methods Sixty patients with MHD and depression who were admitted to the Third Central Hospital of Baoding from May 2010 to May 2012 were randomly divided into control group and treatment group, with 30 cases in each group. Patients in the control group were treated with general antihypertensive drugs. Patients in the treatment group were treated with fluoxetine on the basis of the control group. Before and after treatment, Hamilton Depression Rating Scale (HAMD) score, blood pressure (systolic pressure, diastolic pressure) and clinical effect were observed. Results There was no significant difference in HAMD scores between the two groups before treatment (P> 0.05). After treatment, the HAMD score of the treatment group was lower than that of the control group (P <0.05). HAMD (P <0.05). There was no significant difference in systolic pressure and diastolic pressure between the two groups before treatment (P> 0.05). After treatment, the systolic pressure and diastolic pressure of patients in the treatment group were significantly lower than those before treatment In the control group, the difference was statistically significant (P <0.05). The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion The antihypertensive efficacy of fluoxetine in patients with MHD and depression is significant, which can improve the depression status of patients.