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目的探讨经内镜逆行胰胆管造影(ERCP)术后急性胰腺炎(PEP)的危险因素。方法分析360例诊断性和治疗性ERCP患者的临床资料,对比分析术后PEP发生的危险因素。结果急性胰腺炎病史、括约肌功能障碍(SOD)患者为PEP高危人群,操作中胰管多次显影、乳头多次插管和预切开是PEP的高危因素(均P<0.05),而十二指肠憩室、操作过程中乳头括约肌切开、导丝辅助插管等与PEP无关(均P>0.05)。结论相关危险因素中,患者本身的高危因素和操作技术同样重要,有效预防与规范操作可有效降低术后PEP发生率。
Objective To investigate the risk factors of acute pancreatitis (PEP) after endoscopic retrograde cholangiopancreatography (ERCP). Methods The clinical data of 360 patients with diagnostic and therapeutic ERCP were analyzed, and the risk factors of postoperative PEP were compared. Results Patients with a history of acute pancreatitis and sphincter dysfunction (SOD) were at high risk for PEP. Multiplication of the pancreatic duct during operation, multiple intubation of the nipple and pre-incision were risk factors for PEP (all P <0.05) The bowel diverticulum, sphincterotomy during operation, guide wire assisted intubation and other non-PEP (all P> 0.05). Conclusion Among the relevant risk factors, the patients themselves are at risk factors and operation techniques are equally important. Effective prevention and standardization of operation can effectively reduce postoperative PEP incidence.