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目的 探讨血栓前状态与妊娠高血压综合征 (PIH)的关系及作用。方法 使用流式细胞术(FC)及酶联免疫法 (ELISA)测定PIH患者 5 0例 (PIH组 )和正常妊娠晚期患者 15例 (对照组 )的静脉假血友病因子 (vwFAg)、血小板膜蛋白P选择素 (P selectin)、D 二聚体 (D dimer)和纤维蛋白原 (Fg)的水平变化。并对轻、中、重妊娠高血压综合征组的上述指标进行比较。结果 与对照组相比 ,重度妊娠高血压综合征组血浆vwFAg、P selectin、D dimer、Fg水平均显著升高 (P <0 0 5 )。 结论 重度妊娠高血压综合征患者存在血栓前状态 ,血栓前状态与PIH有关。
Objective To investigate the relationship between prothrombotic state and pregnancy induced hypertension (PIH). Methods Flow cytometry (FACS) and enzyme-linked immunosorbent assay (ELISA) were used to determine the von Willebrand factor (vwFAg), platelet in 50 PIH patients and 15 normal pregnant women (control group) Changes in the levels of P selectin, D dimer and fibrinogen (Fg). And light, moderate and severe pregnancy-induced hypertension group of the above indicators were compared. Results Compared with the control group, the levels of vWFAg, P selectin, D dimer and Fg in severe pregnancy induced hypertension group were significantly increased (P <0.05). Conclusion There are prethrombotic state in patients with severe pregnancy-induced hypertension and the prothrombotic state is related to PIH.