于妊娠16～22周检查母血清甲胎蛋白,可早期预测神经管缺损畸型,这在许多国家已作为常规产前检查项目。此外,母血清甲胎蛋白还可以诊断及指导处理高危妊娠及胎死宫内,国内尚无这方面的报道。本文报道利用中期妊娠引产前后母血清甲胎蛋白的变化作为预测胎死宫内的依据,并评价其临床意义。 Maternal serum alpha-fetoprotein is examined at 16-22 weeks of gestation to predict early abnormalities in neural tube defects, which has been used as a routine prenatal check in many countries. In addition, maternal serum alpha-fetoprotein can also diagnose and guide the treatment of high-risk pregnancy and fetal death, there is no such report in China. This article reports the use of changes in maternal serum alpha-fetoprotein before and after induction of labor in mid-term pregnancy as a basis for predicting intrauterine fetal death and evaluate its clinical significance.