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目的比较异丙酚和七氟烷对小儿体外循环心的肌保护作用。方法 40例先天性心脏病患儿随机分成2组,每组20例。麻醉诱导后,异丙酚组采用异丙酚麻醉维持,七氟烷组采用七氟烷麻醉维持,所有患儿于麻醉前、体外循环结束后、到达ICU即刻、术后6h、12h及24h抽取静脉血,测定血浆肌钙蛋白I(cTnI)及心肌酶CK-MB。结果两组患儿术前基础值血浆CK-MB和cTnI浓度差异无统计学意义;与术前基础值相比,两组患儿体外循环结束后、T0、T6、T12及T24显著升高;与异丙酚组相比,七氟烷组体外循环结束后、T0、T6、T12及T24显著降低。结论七氟烷对小儿体外循环心肌保护作用优于异丙酚。
Objective To compare the protective effects of propofol and sevoflurane on cardiopulmonary bypass. Methods 40 cases of congenital heart disease were randomly divided into two groups, 20 cases in each group. After induction of anesthesia, propofol anesthesia was maintained in the propofol group, sevoflurane anesthesia was maintained in the sevoflurane group, all patients were anesthetized before and after cardiopulmonary bypass, ICU arrived immediately, 6h, 12h and 24h after surgery Venous blood was collected for determination of plasma troponin I (cTnI) and myocardial enzyme CK-MB. Results There was no significant difference in preoperative basal plasma CK-MB and cTnI between the two groups. T0, T6, T12 and T24 of the two groups were significantly increased after cardiopulmonary bypass. Compared with propofol group, sevoflurane group after cardiopulmonary bypass, T0, T6, T12 and T24 significantly decreased. Conclusions Sevoflurane is superior to propofol in cardioprotection in children during cardiopulmonary bypass.