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用动物诱癌实验进行鼻咽癌的病因和发病学研究的工作,在国内已开展多年。1963年我们之一曾在小鼠体内成功地用DMBA异位诱发鼻咽癌,次年王蘅文等用苯并芘原位诱发了鼻咽癌,1973年潘世(山成)等用各类亚硝胺诱发大鼠鼻咽癌成功,其后并发现杂环亚硝胺对大鼠鼻咽有特殊亲和性,皮下注射亚硝胺吗福林诱发鼻咽癌的诱癌率达87%。但这些实验都是用已知强烈致癌物质进行诱癌的,究竟人类鼻咽癌的化学病因与环境中哪些因素有关呢?这是我们须要解决的问题。1976年广东省鼻咽癌化学致癌病因协作组发现中山县鼻咽癌高发地区人民的主食(大米和饮用水)中镍的含量比低发地区为高,最近又测知高
The use of animal cancer-causing experiments to study the etiology and pathogenesis of nasopharyngeal carcinoma has been carried out in China for many years. In 1963, one of us successfully used the DMBA ectopically to induce nasopharyngeal carcinoma in mice. The following year, Wang Yuwen et al. used benzopyrene to induce nasopharyngeal carcinoma in situ. In 1973, Pan Shi (Yan Cheng) and others used each. Nitrosamine-induced nasopharyngeal carcinoma in rats succeeded, and later found heterocyclic nitrosamines have a special affinity for rat nasopharyngeal, subcutaneous injection of nitrosamine morphine to induce nasopharyngeal carcinoma tumor induction rate of 87 %. However, these experiments are based on known carcinogens with strong carcinogens. How does the chemical etiology of human nasopharyngeal cancer relate to environmental factors? This is a problem that we need to address. In 1976, the Guangdong Provincial Collaborative Group of Chemical Carcinogenesis of Nasopharyngeal Carcinoma found that the nickel content of the staple foods (rice and drinking water) of people with high incidence of nasopharyngeal cancer in Zhongshan County was higher than that in low-incidence areas.