为了克服日趋严重的细菌耐药问题,近年研制推出的第三代头孢菌素以其耐酶(对β-丙酰胺酶稳定),高效,对革兰氏阴性细菌作用强,尤其是对绿脓杆菌有效的特点,在临床迅速推广,并已占据细菌性感染化疗药物的重要地位.然而,尽管第三代头孢菌素在临床应用的时间并不长,国内外已有不少耐药细菌出现的报道;许多革兰氏阴性杆菌能迅速对第三 In order to overcome the increasingly serious problem of bacterial resistance, the third-generation cephalosporin developed in recent years is highly effective against Gram-negative bacteria due to its resistance to enzymes (stable to β-propionamidase), especially against pus Bacillus effective features, the rapid promotion in the clinic, and has occupied the important position of bacterial infection chemotherapy drugs.However, although the third-generation cephalosporins in clinical application of time is not long, there have been many resistant bacteria at home and abroad Many Gram-negative bacilli can quickly respond to the third