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目的探讨麝香保心丸治疗老年稳定性心绞痛的临床疗效。方法选取周至县人民医院2014年7月—2016年7月收治的老年稳定性心绞痛患者60例,采用随机数字表法分为对照组与研究组,各30例。对照组给予常规西药治疗,研究组在对照组治疗基础上给予麝香保心丸治疗,两组患者均连续治疗4周。比较两组患者临床疗效、治疗前后心绞痛发作次数与持续时间、主要症状(心绞痛、胸闷、出汗、气促、全身乏力)消失时间及不良反应(口干、眩晕、恶心、失眠等)。结果研究组患者治疗总有效率高于对照组(P<0.05)。治疗前两组患者心绞痛发作次数与持续时间比较,差异无统计学意义(P>0.05);治疗后研究组心绞痛发作次数少于对照组,心绞痛持续时间短于对照组(P<0.05)。研究组患者胸闷、出汗、气促、全身乏力、心绞痛消失时间短于对照组,不良反应发生率低于对照组(P<0.05)。结论麝香保心丸治疗老年稳定性心绞痛的临床疗效确切,可有效改善患者心绞痛症状,保护心肌功能,且安全性高。
Objective To investigate the clinical efficacy of “Shexiang Baoxin Pill” in the treatment of elderly patients with stable angina pectoris. Methods Sixty elderly patients with stable angina pectoris who were admitted to Zhouzhi County People’s Hospital from July 2014 to July 2016 were randomly divided into control group and study group with 30 cases in each group. The control group was given conventional western medicine. The study group was treated with “Shexiang Baoxin Pill” on the basis of the control group. Both groups were treated continuously for 4 weeks. The clinical curative effect, the number and duration of angina pectoris before and after treatment, the disappearance time of main symptoms (angina pectoris, chest tightness, sweating, shortness of breath, generalized fatigue) and adverse reactions (dry mouth, dizziness, nausea and insomnia) were compared between the two groups. Results The total effective rate of treatment in study group was higher than that in control group (P <0.05). The number of angina pectoris and duration in the two groups before treatment were no significant difference (P> 0.05). The number of angina pectoris in the study group was less than that in the control group, and the duration of angina pectoris was shorter than that in the control group (P <0.05). Patients in the study group had shorter chest tightness, sweating, shortness of breath, generalized fatigue, and disappearance of angina than those in the control group. The incidence of adverse reactions was lower in the study group than in the control group (P <0.05). Conclusion Shexiang Baoxin Pill is effective in treating elderly patients with stable angina pectoris. It can effectively improve the symptoms of angina pectoris, protect myocardial function and have high safety.