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目的探究生化检验项目应用于肝硬化诊断的可行性。方法 57例肝硬化患者作为肝硬化组,57例急性肝炎患者作为急性肝炎组,57例健康体检者作为对照组,对三组研究对象进行各项生化指标检测,并将三组研究对象的各项生化指标进行对比,包括天冬氨酸氨基转移酶、谷氨酸氨基转移酶、碱性磷酸酶、胆碱酯酶、总胆红素、直接胆红素、白蛋白、总蛋白、血清透明质酸、Ⅲ型前胶原、层粘连蛋白和Ⅳ型胶原。结果肝硬化组和急性肝炎组患者的天冬氨酸氨基转移酶、谷氨酸氨基转移酶、碱性磷酸酶、总胆红素和直接胆红素水平均明显高于对照组,胆碱酯酶、白蛋白和总蛋白水平均明显低于对照组,差异均具有统计学意义(P<0.05)。肝硬化组和急性肝炎组患者的血清透明质酸、Ⅲ型前胶原、层粘连蛋白和Ⅳ型胶原水平均高于对照组,差异均具有统计学意义(P<0.05)。结论在不同肝病中,常规生化检查指标大小不一,但是天冬氨酸氨基转移酶、谷氨酸氨基转移酶、碱性磷酸酶、总胆红素和直接胆红素均会明显高于健康人群,因此将生化检验项目应用于肝硬化患者的诊断是切实可行的。
Objective To investigate the feasibility of applying biochemical test in the diagnosis of cirrhosis. Methods Fifty-seven patients with liver cirrhosis as the cirrhosis group, 57 acute hepatitis patients as the acute hepatitis group and 57 healthy subjects as the control group. All the biochemical indexes of the three groups were tested, Biochemical indicators were compared, including aspartate aminotransferase, glutamate aminotransferase, alkaline phosphatase, cholinesterase, total bilirubin, direct bilirubin, albumin, total protein, serum clear Hyaluronic Acid, Type III Procollagen, Laminin, and Type IV Collagen. Results The levels of aspartate aminotransferase, glutamate aminotransferase, alkaline phosphatase, total bilirubin and direct bilirubin in patients with cirrhosis and acute hepatitis were significantly higher than those in the control group Enzyme, albumin and total protein levels were significantly lower than the control group, the difference was statistically significant (P <0.05). The levels of serum hyaluronic acid, type Ⅲ procollagen, laminin and type Ⅳ collagen in patients with cirrhosis and acute hepatitis were significantly higher than those in control group (P <0.05). Conclusion In different liver diseases, the indexes of routine biochemical tests vary in size, but aspartate aminotransferase, glutamate aminotransferase, alkaline phosphatase, total bilirubin and direct bilirubin are significantly higher than those of healthy Population, so the biochemical test items for the diagnosis of cirrhosis patients is feasible.