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目的了解慢性阻塞性肺疾病(COPD)患者发生侵袭性肺曲霉病(IPA)的危险因素。方法选择2000年1月至2005年12月郑州大学第一附属医院25例发生IPA的COPD患者,根据EORTC/MSG2002年制定的标准以及血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准,进行回顾性分析。结果确诊IPA7例,临床诊断18例。单因素分析发现,长期使用糖皮质激素、机械通气、过去1年中多次住院与COPD患者发生IPA有关;但多因素Logistic回归分析显示,长期使用糖皮质激素及过去1年中多次住院者是发生IPA的独立危险因素。结论接受长期糖皮质激素治疗及过去一年中多次住院的COPD患者是发生IPA的危险因素。
Objective To understand the risk factors of invasive pulmonary aspergillosis (IPA) in patients with chronic obstructive pulmonary disease (COPD). Methods 25 COPD patients with IPA who developed IPA at the First Affiliated Hospital of Zhengzhou University from January 2000 to December 2005 were retrospectively analyzed according to the criteria of EORTC / MSG2002 for the diagnosis of invasive fungal infection in patients with ICH / malignant tumor Sexual analysis. Results confirmed IPA7 cases, 18 cases of clinical diagnosis. Univariate analysis found that long-term use of glucocorticoids, mechanical ventilation, multiple hospitalizations in the past year and COPD patients with IPA occurred; but multivariate logistic regression analysis showed that long-term use of corticosteroids and multiple hospitalizations in the past year Is an independent risk factor for IPA. Conclusions Long-term glucocorticoid therapy and COPD patients hospitalized multiple times during the past year are risk factors for IPA.