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[目的]观察安博诺对高原地区老年高血压患者的临床疗效。[方法]以青海省海西州人民医院2006年12月～2009年3月收治的老年(≥60岁)高血压患者63例被随机分为治疗组33例和对照组30例,分别采用每日晨服安博诺(厄贝沙坦氢氯噻嗪150mg/12.5/mg),厄贝沙坦150mg和吲达帕胺2.5mg,疗程均为8周,观察两组治疗前后血压、24h动态血压及生化指标。[结果]治疗后两组血压均有明显下降,治疗组有效率及血压、24h动态血压与治疗前比较P﹤0.01,但组间比较差异无统计学意义P﹥0.05。两组服药前后生化指标无明显改变。[结论]安博诺能安全有效地降低高原地区老年高血压,副作用小,对代谢无影响,是高原地区老年高血压患者选择的理想药物。
[Objective] To observe the effect of Amboxon on elderly hypertensive patients in plateau area. [Methods] Sixty-three elderly patients (≥60 years old) with hypertension who were admitted to Haixi People’s Hospital of Qinghai Province from December 2006 to March 2009 were randomly divided into treatment group (n = 33) and control group (n = 30) Day morning service Ambrose (irbesartan hydrochloride hydrochlorothiazide 150mg / 12.5 / mg), irbesartan 150mg and indapamide 2.5mg, treatment were 8 weeks, the two groups were observed before and after treatment of blood pressure, 24h ambulatory blood pressure and biochemical markers . [Results] After treatment, the blood pressure of both groups were significantly decreased. The effective rate and blood pressure of the treatment group and the ambulatory blood pressure of 24h were P <0.01 compared with those before treatment, but there was no significant difference between the two groups (P> 0.05). Before and after taking the two groups of biochemical indicators no significant change. [Conclusion] Ambono can safely and effectively reduce the elderly hypertension in the plateau area with small side effects and no effect on metabolism. It is an ideal drug of choice for elderly patients with hypertension in the plateau area.