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文中介绍收治肾病综合征115例。82例单独用强的松治疗的患儿中58例完全缓解。完全缓解率为70.7％,如将部分缓解的病例包括在内,则总的缓解率为85.4％。但是这组的复发率高,41例随访病人中有29例复发,复发者的平均缓解期为3.23月,复发率为70.7％。其余12例平均随访13.96月未复发。 37例强的松治疗无效或激素依赖或强的松治疗后复发的病人,采用环磷酰胺加小剂量强的松治疗,其中27例完全缓解(73％)。总的缓解率(包括部分缓解在内)为86.5％。随访31例,其中8例复发,复发者平均缓解期为11.4月。其余23例平均随访15.3月未复发,复发率为25.8％,环磷酰胺组的复发率较强的松组为低,统计学上具有显著性(P<0.01),比较两组复发者的缓解期和未复发者的随访期表明,环磷酰胺组的缓解期比强的松组明显延长(P<0.01)。
The article introduced the treatment of nephrotic syndrome in 115 cases. Of the 82 children treated with prednisone alone, 58 were completely relieved. The complete remission rate was 70.7%. If the partial remission was included, the overall remission rate was 85.4%. However, the recurrence rate was high in this group, with 29 of the 41 follow-up patients relapsed. The average remission rate was 3.3 months, with a recurrence rate of 70.7%. The remaining 12 cases were followed up for an average of 13.96 months without recurrence. Thirty-seven patients with prednisone who were ineffective or who relapsed after hormone-dependent or prednisone treatment were treated with cyclophosphamide plus prednisone in a small dose, 27 of them in complete remission (73%). The overall response rate (including partial response) was 86.5%. Follow-up 31 cases, of which 8 cases of recurrence, the average recurrence of remission was 11.4 months. The remaining 23 cases were followed up for 15.3 months on average without recurrence, with a recurrence rate of 25.8%. The cyclophosphamide group had a lower recurrence rate and a statistically significant difference (P <0.01) The follow-up periods of patients with and without recurrence showed that the remission period of cyclophosphamide group was significantly longer than that of prednisone group (P <0.01).