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目的研究薄层液基细胞学(TCT)检查用于预防子宫颈癌和癌前病变的筛查与传统巴氏涂片(CS)相比的优越性。方法将门诊以宫颈病变就诊的病人随机分为观察组和对照组,两组数据都消除了任何对高危病人偏向选择TCT方法的可能。观察组1100例用TCT检测;对照组1071例用CS方法。对两种方法的标本不满意率及宫颈病变的阳性检出率进行了比较.并对两种方法与组织学的符合率进行了比较。结果TCT检测标本的不满意率(0.45%)明显低于传统宫颈细胞涂片(14.01%);TCT对子宫颈癌及癌前病变的阳性诊断率明显高于CS检查。TCT和CS检查与阴道镜下活检病理结果符合率分别为LSIL:78.43(40/51)和55.56%(20/36),HSIL:90.63%(29/32)和46.15%(6/13),差异有显著性。结论在预防性筛查宫颈癌和癌前病变中薄层液基细胞学(TCT)检测方法优于传统涂片(CS)方法,大大提高了标本满意度和宫颈病变的阳性诊断率。
Objective To investigate the superiority of TLCT in the screening of cervical cancer and precancerous lesions compared with traditional Pap smears (CS). Methods Outpatients with cervical lesions were randomly divided into observation group and control group, and the data of two groups all eliminated the possibility of choosing TCT for high-risk patients. 1100 cases of observation group using TCT test; control group of 1071 cases with CS method. The dissatisfaction rate between the two methods and the positive detection rate of cervical lesions were compared, and the coincidence rates of the two methods and histology were compared. Results The unsatisfactory rate of TCT (0.45%) was significantly lower than that of conventional cervical smear (14.01%). The positive rate of TCT in cervical cancer and precancerous lesions was significantly higher than that of CS. The coincidence rates of TCT, CS and biopsy results were LSIL: 78.43 (40/51) and 55.56% (20/36), HSIL: 90.63% (29/32) and 46.15% (6/13) The difference was significant. Conclusion The detection of TCT in precancerous cervical cancer and precancerous lesions is superior to the traditional smear (CS) method, which greatly improves the positive rate of specimen satisfaction and cervical lesions.