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目的:探讨影响喉癌手术后生存的相关危险因素。方法:回顾1997年1月-2006年12月在我科行喉癌手术治疗的89例患者,分析肿瘤因素、宿主因素及辅助治疗因素对术后生存的影响。结果:全组术后5年生存率70.7%(63/89),肿瘤T分期、颈部淋巴结是否转移及手术切缘状态是影响喉癌手术预后的独立危险因素。对于进展期喉癌,如适应症选择合理,行全喉切除及根治性喉部分切除预后无统计学差异。结论:早期诊断并选择合理的术式,尤其一些保留或重建喉功能的术式加合理的颈淋巴结清扫,同时确保手术安全切缘是提高喉癌术后肿瘤和喉功能效果的关键。
Objective: To investigate the related risk factors of survival after laryngeal cancer surgery. Methods: The clinical data of 89 patients with laryngeal cancer treated in our department from January 1997 to December 2006 were retrospectively analyzed. The effects of tumor factors, host factors and adjuvant therapy on postoperative survival were analyzed. Results: The 5-year postoperative survival rate of 70.7% (63/89), tumor T stage, cervical lymph node metastasis and surgical margin status were independent risk factors for the prognosis of laryngeal cancer. For advanced laryngeal cancer, such as the choice of indications reasonable, total laryngectomy and radical throat resection prognosis was no significant difference. Conclusion: Early diagnosis and selection of reasonable surgical procedures, especially surgical resection plus reasonable neck lymph node dissection to preserve or reconstruct the laryngeal function, and to ensure surgical safety of the margins are the keys to improve the tumor and laryngeal function after laryngeal cancer surgery.