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作者等认为在非洲大陆存在着对四胺喹啉有抗性的恶性疟问题,迄今尚未证实。为了评价上沃尔特博博-迪乌拉索地区了的当地恶性疟对药物的反应,用氯喹治疗100例,总剂量为每公斤体重25毫克,连服3天。完成治程列入统计的86例。所观察的病例都来自门诊,没有严重感染的,大多数和疟原虫有过多次接触,具有半免疫力。临床症状一般在治疗开始后2～3天内消失。原虫血症很快地降低,最迟在开始治疗后的第4天全部转阴。经过两个月的追踪观察,86例中有81例没有见到原虫再现;另5例
The authors believe there is a problem of falciparum malaria resistant to tetramine in the African continent, which has not yet been confirmed. In order to evaluate the response of the local falciparum malaria to the drug in Upper Walter Bobo-Dioulasso region, 100 patients were treated with chloroquine at a total dose of 25 mg / kg body weight for 3 consecutive days. 86 cases completed the treatment included in the statistics. The observed cases are all outpatient clinics, there is no serious infection, and most have had multiple contacts with Plasmodium, with semi-immunity. Clinical symptoms generally disappear within 2 to 3 days after the start of treatment. Parasitemia is rapidly reduced and is fully negative at 4 days after the start of treatment. After two months of follow-up observation, 81 of the 86 patients did not see protozoan recurrence; the other 5 patients