论文部分内容阅读
抑郁综合征胺类假说的基本机制是中枢去甲肾上腺素(NA)和5-羟色胺(5-HT)的缺乏。在体内四氢蝶呤是苯丙氨酸向酪氨酸变化及酪氨酸、色氨酸羟化的主要辅助因子,并可限制5-HT、NA和多巴胺合成的速度。新蝶呤在体内经过一系列的中间过程生成四氢蝶呤和生物蝶呤。新蝶呤和生物蝶呤的比率可作为四氢蝶呤的合成标志,比率增高意味着新蝶呤未能转化为生物蝶呤,因而不能产生四氢蝶呤。本文作者通过检测尿中新蝶呤和生物蝶呤的比率来研究能否作为抑
The underlying mechanism of the depression syndrome amine hypothesis is the absence of central norepinephrine (NA) and serotonin (5-HT). In vivo, tetrahydronopterin is a major cofactor for phenylalanine to tyrosine and tyrosine and tryptophan hydroxylation, and limits the rate of 5-HT, NA and dopamine synthesis. Neopterin undergoes a series of intermediate processes to produce tetrahydropterin and biopterin in the body. The ratio of neopterin to biopterin can be used as a marker for the synthesis of tetrahydropterin. An increase in the ratio means that neopterin can not be converted to biopterin and therefore does not produce tetrahydropterin. The authors investigated whether inhibition could be achieved by testing urinary neopterin and biopterin ratios