原发难治老年B-ALL患者CD19 CAR-T联合来那度胺治疗后长期生存1例

来源 :临床肿瘤学杂志 | 被引量 : 0次 | 上传用户：niwai

【摘要】

：

急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)是常见的造血系统恶性肿瘤,其发生于老年患者可因老年人群机体功能减退等导致治疗更为困难,预后更差,且一旦复发或难治(R/R),常规化疗再缓解率极低。本例老年B细胞-ALL(B-ALL)患者原发耐药,CD19嵌合抗原受体T细胞(CAR-T)免疫治疗后采用来那度胺联合白介素-2(IL-2)维持治疗,目前已持续微小残留病(MRD)阴性完全缓解(CR)超过45个月。现报告如下。

【作者】

：

苏燕熊媛媛艾昊王倩魏旭东宋永平尹青松

【机构】

：

郑州大学附属肿瘤医院

【出处】

：

临床肿瘤学杂志

【发表日期】

：

2021年7期

【关键词】

：

急性淋巴细胞白血病老年 CD19嵌合抗原受体T细胞治疗来那度胺白介素-2

【基金项目】

：

河南省医学科技攻关计划资助项目(省部共建)(201701028)。

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原发难治老年B-ALL患者CD19 CAR-T联合来那度胺治疗后长期生存1例

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