在许多抗病毒感染免疫中,细胞介导免疫（CMI）应答是很有益的。CMI可由减毒病毒和重组病毒或重组细菌等诱导产生,因它们在免疫宿主体内表达外源抗原。最近证明,非复制型质粒DNA表达载体经肌肉注射或粒子轰击后,可以在原位表达外源蛋白。所以,这种注射DNA的方法是产生免疫应答的有效手段。本文作者对流感病毒血凝素（HA）和核蛋白（NP）DNA疫苗的使用剂量与免疫原性及基于细胞和体液免疫的保护效 In many antiviral infections, the cell-mediated immune response (CMI) is very beneficial. CMI can be induced by attenuated viruses and recombinant viruses or recombinant bacteria, etc. because they express foreign antigens in the host of the immune host. It has recently been demonstrated that non-replicating plasmid DNA expression vectors can express exogenous proteins in situ upon intramuscular or particle bombardment. Therefore, this method of DNA injection is an effective means of generating an immune response. The authors have shown that the dose and immunogenicity of the influenza virus hemagglutinin (HA) and nucleoprotein (NP) DNA vaccines and the protective effect based on cellular and humoral immunity