患者男,48岁,因全身皮肤瘙痒、变黑月余,左上腹不适3d于1990年11月27日入院。自诉于10月初开始无任何诱因下出现全身皮肤逐渐变黑,伴轻度瘙痒,按“皮炎”治疗无效。入院前3 d自觉左上腹不适,食量稍减,二便正常。家族史无异常。 休检:全身皮肤棕褐色、粗糙,胫前皮肤明显角化呈苔藓样变。颈背部皮肤均有抓痕及灰黑色乳头样增生。颊粘膜 The patient male, 48 years old, was admitted to hospital on November 27, 1990 due to pruritus of the body and darkening of the body for more than 2 months. Since the beginning of October, the self-accusation began to show a blackening of the body’s skin without any inducement, and with mild itching, the treatment according to “dermatitis” was ineffective. 3 days before admission, she felt uncomfortable in the left upper quadrant and her food intake decreased slightly. There is no abnormal family history. Check-ups: The skin of the body is tan and rough, and the skin is markedly keratinized and moss-like. The skin on the back of the neck was scratched and gray-black papillary hyperplasia. Buccal mucosa