摘要目的 (a)研究超顺磁性氧化铁(USPIO)增强MRI在非酒精性脂肪肝的合适扫描时间和剂量;(b)评估在非酒精性脂肪肝中肝脏对于USPIO的摄取是否会降低;(c)研究USPIO增强MR成像对于诊断非酒精性脂肪肝和单纯性肝脂肪变性的准确性。材料与方法该前瞻性的研究得到了当地伦理委员会的批准,所有病人均签署知情同意书。在注射USPIO时和之后72 h采集量化的肝脏R2*MR影像,被试对 Abstract Objectives (a) To investigate the appropriate scan time and dose of enhanced paramagnetic iron oxide (USPIO) in non-alcoholic fatty liver; (b) to assess whether the hepatic uptake of USPIO is reduced in non-alcoholic fatty liver; c) To study the accuracy of USPIO-enhanced MR imaging in the diagnosis of non-alcoholic fatty liver and simple hepatic steatosis. Materials and Methods The prospective study was approved by a local ethics committee and all patients signed informed consent. Quantified liver R2 * MR images were collected at 72 h after USPIO injection and were tested