目的　探讨血糖、C反应蛋白 (CRP)在肺炎并全身炎症反应综合征 (SIRS)患儿中的改变及其意义。方法　选择 6 2例肺炎并SIRS患儿 ,动态测定血糖及CRP ,同时选择非SIRS的肺炎患儿和正常儿童作对照。结果　非SIRS组血糖与正常对照组比较差异无显著意义 (P >0 0 5 ) ,而CRP显著高于正常对照组 (P<0 0 1) ;SIRS组血糖和CRP均显著高于非SIRS组 (P <0 0 1) ;具有SIRS诊断标准 3项以上的患儿 4 8h血糖和第 5dCRP持续不降 ,发生多器官功能不全综合征 (MODS)率明显增高 (P <0 0 1)。结论　肺炎时血糖和CRP联合检测有助于准确评估病情的危重度 ,血糖和CRP持续性升高 ,预示着MODS的可能发生。 Objective To investigate the changes and significance of blood glucose and C-reactive protein (CRP) in children with pneumonia and systemic inflammatory response syndrome (SIRS). Methods Sixty-two children with pneumonia and SIRS were selected and their blood glucose and CRP were measured dynamically. At the same time, children with non-SIRS pneumonia and normal children were selected as controls. Results The blood glucose of non-SIRS group had no significant difference compared with that of the normal control group (P> 0.05), while the CRP was significantly higher than that of the normal control group (P <0.01). The blood glucose and CRP of the SIRS group were significantly higher than those of the non-SIRS group (P <0.01). The 48 h blood glucose and 5 d CRP in children with more than 3 SIRS criteria continued to decrease, and the rate of multiple organ dysfunction syndrome (MODS) increased significantly (P <0.01). Conclusions The combined detection of blood glucose and CRP in pneumonia can help to accurately assess the severity of the disease, and the persistent increase of blood glucose and CRP, indicating the possible occurrence of MODS.