目的　探讨新生儿窒息与多器官功能不全综合征的关系。方法　根据全国小儿急诊医学组拟定的MOF诊断标准进行临床分析。结果　 2 82例新生儿窒息患儿 ,在MODS病程发展过程中部分出现一过性肝、肾、胃肠道和脑等器官功能受损的表现 ,最终进展为MODS 79例 ,占 2 8%。MODS总的病死率为43 1%。结论　MODS是重症患儿中常见病症 ;MODS进展至器官功能衰竭前存在器官功能受损的表现 ,应予高度重视并早期干预 Objective To investigate the relationship between neonatal asphyxia and multiple organ dysfunction syndrome. Methods According to the national MOF emergency medical group MOF diagnostic criteria for clinical analysis. Results In 82 cases of neonatal asphyxia, 79 cases (28%) were finally diagnosed as MODS with transient damage of the liver, kidney, gastrointestinal tract and brain during the development of MODS. Overall MODS mortality was 43.1%. Conclusion MODS is a common disease in critically ill children. The performance of organ dysfunction before MODS progression to organ failure should be given high priority and early intervention