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目的 评价半导体激光不同功率不同能量下肝组织坏死范围 ,寻求在合适功率、能量下的肝组织炭化坏死区域 ,为肝恶性肿瘤半导体激光治疗提供可靠的依据。方法 取 10只兔子 ,分别在 1W、2W、3W下用半导体激光烧灼 ,所用能量分别为 2 0 0J、40 0J、6 0 0J、80 0J、10 0 0J,测量靶区域肝组织炭化和坏死的直径。结果 10 0 0J,激光功率分别为 1W、2W时 ,肝组织炭化和坏死的直径随功率增大分别由 4 3mm和 7 8mm变为 10 4mm和 2 1 9mm ;为 3W时 ,肝组织炭化和坏死的直径与 2W时比较无明显的变化 (F =15 19,1142 3;P值均 <0 0 1)。在 2W功率下 ,肝组织炭化和坏死的直径与能量成正比 ,肝组织炭化和坏死的直径之间成相关性 (F =44 91 7,10 0 19 6 ;P值均 <0 0 1)。结论 半导体激光肝肿瘤凝固术是安全可行的 ,为进一步临床研究提供有参考价值的实验数据。
Objective To evaluate the extent of hepatic tissue necrosis under different powers and densities of semiconductor lasers, and to search for areas of carbonization and necrosis of liver tissue with appropriate power and energy to provide a reliable basis for the treatment of hepatic malignancies. Methods Ten rabbits were burned at 1W, 2W and 3W with a semiconductor laser. The energy used was 200J, 400J, 600J, 800J, 100J, and the target area was measured for carbonization and necrosis of liver tissue. diameter. RESULTS 100 0 0J, when the laser power was 1 W and 2 W, the diameter of liver carbonization and necrosis increased from 4 3mm and 78mm to 104mm and 219mm, respectively; the carbonization and necrosis of liver tissue was 3W. There was no significant change in diameter between the 2W and 2W (F = 15 19,1142 3; P values were <0 0 1). At 2W power, the diameter of carbonized and necrotic liver tissue is directly proportional to the energy, and the diameter of liver carbonization and necrosis is correlated (F = 44 91 7, 10 0 19 6 ; P < 0 01). Conclusions Laser coagulation with hepatic neoplasms is safe and feasible. It provides valuable experimental data for further clinical studies.