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膀胱癌的特点之一是多发性,即除临床检查可见的病灶外还存在一些亚临床病灶,其中包括早期癌和癌前病变。因此很易复发,需要进行多次治疗,故给患者造成很大痛苦。笔者在国内首先应用N-丁基-N-(4-羟丁基)亚硝胺(简称BBN)诱发成功大鼠膀胱移行细胞癌模型,并在光动力学实验治疗中取得满意的疗效,尤其是乳头瘤在激光血卟啉作用下发生萎缩消退变化,认为BBN诱发大鼠膀胱移行细胞癌和癌前病变模型是开展膀胱癌防治研究的较理想的动物实验模型。据报道,抗癌乙片和维胺酯对食管上皮癌变的阻断作用已经在动物实验和高风险人群试验中获得成功。本实验观察抗癌乙片和维胺酯对大鼠膀胱粘膜上皮增生癌变的阻断作用,以为膀胱癌早期治疗提供依据。
One of the hallmarks of bladder cancer is multiple, that is, there are subclinical lesions in addition to the lesions seen on clinical examinations, including early cancers and precancerous lesions. Therefore, it is very easy to relapse and requires multiple treatments, which causes great suffering to the patient. The author first applied N-butyl-N-(4-hydroxybutyl) nitrosamine (abbreviated as BBN) to induce a successful rat bladder transitional cell carcinoma model and achieved satisfactory results in photodynamic experimental treatment. It is the papilloma under the laser hematoporphyrin shrinkage subsided changes, that BBN-induced rat bladder transitional cell carcinoma and precancerous lesions model is the development of bladder cancer prevention and treatment of animal research ideal model. According to reports, the blocking effect of anti-cancer tablets and vitamin on the carcinogenesis of esophageal epithelium has been successfully tested in animal experiments and high-risk populations. This experiment observed the blocking effect of anti-cancer tablets and vitamide on rat bladder epithelial hyperplasia and canceration to provide basis for early treatment of bladder cancer.