论文部分内容阅读
实验用乌拉坦麻醉、箭毒制动、人工呼吸的大鼠。将谷氨酸注入岛皮层（INS）以及将P物质（SP）注入外侧下丘脑／穹窿周围区（LH／PF）或室旁核均引起升压反应。INS-升压反应可被中央杏仁核（AC）内预先注射普鲁卡因或谷氨酸二乙酯（GDEE，谷氨酸拮抗剂）以及LH／PF内注射[D－Pro2，D-Phe7，D－TrP9]（DPDPDT，SP拮抗剂）明显衰减，但LH／PF内GDEE预处理对该反应无明显影响。室旁核内预先注射普鲁卡因或DPDPDT也使INS-升压反应显著减小。鉴于我们的其它工作曾显示LH／PF和室分核都介导AC-升压反应，上述结果提示：INS通过兴奋AC（谷氨酸受体）进而激活LH／PF和室旁核（SP受体），是其升压反应机理的重要组成部分。
Experiment with urethane anesthesia, arrow poisoning brake, artificial respiration in rats. Injecting glutamate into the insular compartment (INS) and injection of substance P (SP) into the lateral hypothalamic / vault peripheral area (LH / PF) or paraventricular nucleus both cause a step-up response. The INS-boost reaction can be pre-injected with procaine or diethyl glutamate (GDEE, a glutamate antagonist) and LH / PF injection in the central amygdala (AC) [D-Pro2, D-Phe7 , D-TrP9] (DPDPDT, SP antagonist), but pretreatment with GDEE in LH / PF had no significant effect on this reaction. Pre-injection of procaine or DPDPDT in the paraventricular nucleus also significantly reduced the INS-boost response. In view of our other work showing that both LH / PF and ventricular nuclei mediate AC-boost reactions, the above results suggest that INS activates LH / PF and paraventricular nucleus (SP receptors) by stimulating AC (glutamate receptors) , Is an important part of its boosting reaction mechanism.