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2-甲基-1,5-苯并硫氮杂草-4(5H)-酮(1a)与不同的氯化试剂——五氯化磷、三氯氧磷和氯化砜在不同的条件下氯化,可分别生成:2-甲基-4-氯-1,5-苯并硫氮杂草(2a)、2-氯-4-甲基-1,5-苯并硫氮杂草(3a)、2-二氯甲基苯并噻唑(5)、2-三氯甲基苯并噻唑(6)和2-甲基-1,5-苯并硫氮杂草-4(5H)-酮盐酸盐(4)。2-甲基4-氯-1,5-苯并硫氮杂草与醇钠反应生成相应的2-甲基-4-烷氧基-1,5-苯并硫氮杂草外,还可以分离到它的2,4-异构体,2-烷氧基-4-甲基-1,5-苯并硫氮杂??。产物的结构均经元素分析、红外光谱、~1H和~(13)C核磁共振谱和质谱鉴定.
2-Methyl-1,5-benzothiazepin-4 (5H) -one (1a) with different chlorination reagents - phosphorus pentachloride, phosphorus oxychloride and chlorinated sulfone under different conditions Under the chlorination, 2-methyl-4-chloro-1,5-benzothiazepine (2a), 2-chloro-4-methyl-1,5-benzothiazepine (5), 2-trichloromethylbenzothiazole (6) and 2-methyl-1,5-benzothiazin-4 (5H) -one hydrochloride (4). Reaction of 2-methyl 4-chloro-1,5-benzothiazepine with sodium alcoholate gives the corresponding 2-methyl-4-alkoxy-1,5-benzothiazepine, Its 2,4-isomer, 2-alkoxy-4-methyl-1,5-benzothiazepine was isolated. The structures of the products were identified by elemental analysis, IR, ~ 1H and ~ (13) C NMR and MS.