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目的比较米索前列醇（misoprostol，以下简称米索）重复给药与米索加破膜和方式催产素静滴两种引产方法的效果。方法选择足月妊娠、单胎头位、米索50μg阴道穹窿上药后3h未临产的初产妇102例，分为A组（60例，50μg米索重复上药）和B组（42例，加破膜和/或催产素静滴）。结果A组和B组引产成功率分别是93．3％、92．9％。A组潜伏期、活跃期及第二产程明显短于B组。而宫缩过强、羊水粪染、胎儿窘迫、新生儿窒息、产后出血发生率及手术产率明显高于B组。结论首次米索50μg阴道穹窿上药后3h未临产者，加破膜和/或催产素静滴引产成功率高，较重复上药安全。
Objective To compare the effects of misoprostol (Misoprostol) repeated administration with misoprostol and misoprostol and oxytocin intravenous infusion. Methods A total of 102 primiparae women were enrolled in this study. A total of 102 primiparae were randomly divided into group A (60 cases, 50 μg misoprostol) and group B (42 cases) Plus rupture of membranes and / or oxytocin). Results The success rates of induction of labor in group A and group B were 93.3% and 92.9% respectively. A group of incubation period, active stage and the second stage of labor was significantly shorter than the B group. The contractions too strong, meconium-stained amniotic fluid, fetal distress, neonatal asphyxia, the incidence of postpartum hemorrhage and surgical yield was significantly higher than the B group. Conclusions The first success rate of misoprostol and / or oxytocin intravenous infusion without induction of labor is 3h after administration of 50μg misoprostol on vaginal vault.