Objective: To observe the therapeutic effect of acupuncture in treatment of migraine and the accompanied changes of plasma OGRP and SP. Methods: 186 migraine patients were randomly divided into acupuncture group (n=126) and medication group (n=60). Acupoints used were Taichong (LR 3), Xingjian (LR 2), Fengchi (GB 20) and Yanglingquan (GB 34). Patients of the medication (control) group were asked to take Nimodipine 30 mg (3 times per day), Sibelium 5 mg (once every night), and Ergotamine caffeine (taken curing attack). Plasma OGRP and SP contents were detected by using radioimmunoassay. Results: The therapeutic effect of acupuncture was significantly su- perior to that of medication group (P < 0. 01). In migraine patients, plasma CGRP and SP levels were significantly higher than those of normal people (P <0. 01). After acupuncture treatment, CGRP and SP levels lowered obviously (P<0.05).