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γ-氨基丁酸(GABA)是脑组织中的游离氨基酸,GABA是中枢神经系统中最重要的抑制性神经递质。癫痫的发病与GABA的消长密切相关,当脑内的GABA含量降低时癫痫易于发生。通过平痫冲剂对实验性癫痫幼龄大鼠脑组织中GABA含量的影响,探讨平痫冲剂抗癫痫的作用机制。实验结果显示平痫冲剂能升高实验性癫痫大鼠脑组织中GABA的含量,与空白对照组对比有显著性意义;其平痫冲剂抗癫痫的作用机制可能是通过抑制大脑颞叶皮质及海马兴奋性神经递质受体的活性与表达,从而降低大脑皮质的兴奋性,有效抑制癫痫的形成及发展。
Gamma-aminobutyric acid (GABA) is a free amino acid in brain tissue. GABA is the most important inhibitory neurotransmitter in the central nervous system. The onset of epilepsy is closely related to the growth and decline of GABA, and epilepsy is prone to occur when the content of GABA in the brain is reduced. Through the influence of Pingxian Granules on the content of GABA in the brain tissue of young rats with experimental epilepsy, the mechanism of antiepileptic effect of Pingxian Granules was discussed. The experimental results showed that Pingxian granules can increase the content of GABA in the brain tissue of experimental epileptic rats, and have significant significance compared with the blank control group. The mechanism of action of Pingxian granules against epilepsy may be through inhibition of cerebral cortex and hippocampus. Excitatory neurotransmitter receptor activity and expression, thereby reducing the excitability of the cerebral cortex, effectively inhibit the formation and development of epilepsy.