论文部分内容阅读
目的 比较阿克他利和甲氨喋呤对类风湿关节炎(RA)的疗效和安全性。方法 分别由安徽医科大学附属医院、上海光华医院、安徽省立医院、同济医科大学附属协和医院 ,中国医科大学附属医院 ,按照 1∶1、1∶1、2∶1、2∶1、2∶1的比例 ,将RA患者随机分为 2组 ,阿克他利完成 313例 ,阿克他利口服 10 0mg ,tid× 12wk ,甲氨喋呤完成 16 7例 ,口服甲氨喋呤 10 0mg ,qw× 12wk。 结果 阿克他利总有效率6 8 15 % ,甲氨喋呤总有效率为 76 6 5 % ,经Ridit分析 ,两组比较差异无显著性 (P >0 0 5 ) ,不良反应发生率分别为6 39%和 2 2 75 % ,差异有显著性 (P <0 0 1)。结论 阿克他利治疗类风湿关节炎的疗效与甲氨蝶呤相似 ,耐受性明显好于甲氨喋呤。
Objective To compare the efficacy and safety of acetalit and methotrexate against rheumatoid arthritis (RA). Methods The patients were randomly divided into two groups: the Affiliated Hospital of Anhui Medical University, Shanghai Guanghua Hospital, Anhui Provincial Hospital, Tongji Medical University Affiliated Union Hospital and China Medical University Affiliated Hospital, 1 ratio of RA patients were randomly divided into two groups, the final completion of the Aktarianosis 313 cases, the metopril oral dose of 10mg, tid × 12wk, methotrexate completed 167 cases of oral methotrexate 10 0mg, qw × 12wk. Results The total effective rate was 6 8 15%, and the total effective rate of methotrexate was 76 6 5%. There was no significant difference between the two groups (P> 0.05) by Ridit analysis and the incidence of adverse reactions 639% and 2 2 75% respectively, with significant difference (P <0.01). Conclusion Acitreli treatment of rheumatoid arthritis with methotrexate efficacy similar to tolerance was significantly better than methotrexate.