口咽和阴道念珠菌病是最常见的真菌感染性疾病,主要由白假丝酵母菌(简称白念珠菌)引起。有研究提示局部免疫在宿主对念珠菌病的免疫中发挥重要作用,白念球菌感染中口腔和阴道黏膜部位有细胞因子和趋化因子产生。由于黏膜上皮细胞在对微生物的应答中可产生多种细胞因子和趋化因子,作为一种共生的微生物,白念珠菌与黏膜的上皮细胞密切联系,因此研究白念珠菌对黏膜上皮细胞分泌趋化因子和细胞因子的影响有重要意义。有鉴于此,作者以白念珠菌与原代的口腔和阴道黏膜上皮 Oropharyngeal and vaginal candidiasis is the most common fungal infectious disease, mainly caused by Candida albicans (Candida albicans). Studies have shown that local immunity plays an important role in the host immune response to candidiasis, Candida albicans infection in the oral cavity and vaginal mucosa cytokines and chemokine production. As mucosal epithelial cells in response to microorganisms can produce a variety of cytokines and chemokines, as a symbiotic microorganisms, Candida albicans and mucosal epithelial cells are closely linked, so Candida albicans secretion of mucosal epithelial cells The impact of chemokines and cytokines is of great importance. In view of this, the author of C. albicans with the original oral and vaginal mucosal epithelium