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本实验通过弗氏完全佐剂诱发兔膝关节炎（一种迟发型过敏反应），临床表现与关节病理的改变接近于人类的类风湿性关节炎。主要病理变化是滑膜细胞的增生、层次增多，有的区域滑膜呈绒毛伏突起，血管扩张充血，淋巴细胞弥漫性浸润，间质水肿，软骨轻度破坏。尿素是人体蛋白质的代谢产物，由肾脏排出。尿素注入膝关节腔后，使渭膜炎的绒毛结节坏死，细胞萎缩，空泡样变性，微绒毛减少，淋巴细胞浸润减少，成纤维细胞增生，对软骨无影响。
In this experiment, rabbit knee arthritis (a delayed-type hypersensitivity reaction) was induced by Freund’s complete adjuvant. The clinical manifestations and pathological changes of arthritis were similar to those of human rheumatoid arthritis. The main pathological changes are synovial cell hyperplasia, the level increased, some areas of the synovium was villous prominence, vasodilation and congestion, diffuse lymphocytic infiltration, interstitial edema, cartilage mild destruction. Urea is the body’s protein metabolites, from the kidneys. After injection of urea into the knee joint cavity, villous nodules of uveitis are necrotic, cell atrophy, vacuolar degeneration, decrease of microvilli, decrease of lymphocyte infiltration and proliferation of fibroblasts, and have no effect on cartilage.