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本文收治年龄、病程均相似的原发性高血压患者60例,随机分成两组,分别口服复方哌唑嗪或复方降压1-2片,tid共3 Wk。结果复方哌唑嗪组降压总有效率为90％,而复方降压片组则为70％,(p<0.05)。用复方哌唑嗪患者的收缩压,平均降低3.1±0.4 kpa(23.6±2.7 mmHg),其舒张压平均降低2.50±0.05kpa(18.6±0.4mmHg);用复方降压片患者的收缩压平均降低1.05±0.15 kpa(7.9±1.2 mmHg),其舒张压平均降低0.94±0.77kpa(7.1±5.8 mmHg),(p<0.001)。在服复方哌唑嗪过程中,偶有口干、胃肠道反应。作者等认为复方哌唑嗪降压作用强而持久、副作用小,适用于Ⅱ-Ⅲ期高血压,值得推广应用。
This treatise age and duration are similar in 60 patients with essential hypertension, were randomly divided into two groups, respectively, oral compound prazosin or compound antihypertensive 1-2 tablets, tid a total of 3 Wk. Results The total effective rate of the compound prazosin group was 90%, while that of the compound dipyridamole group was 70% (p <0.05). Systolic blood pressure decreased by 3.1 ± 0.4 kpa (23.6 ± 2.7 mmHg) on average with systolic blood pressure (P <0.05), while mean systolic blood pressure decreased by 2.50 ± 0.05 kPa (18.6 ± 0.4 mmHg) 1.05 ± 0.15 kPa (7.9 ± 1.2 mmHg), with an average decrease of 0.94 ± 0.77 kPa (7.1 ± 5.8 mmHg) in diastolic blood pressure (p <0.001). In the service compound prazosin process, occasional dry mouth, gastrointestinal reactions. The authors believe that the compound prazosin strong and long-lasting antihypertensive effects, side effects, suitable for stage Ⅱ-Ⅲ hypertension, it is worth promoting the application.