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目的探讨血清超敏C反应蛋白(hs-CRP)、肌钙蛋白-I(cTnI)与新生儿缺氧缺血性脑病(HIE)病情严重程度的相关性。方法以60例HIE患儿作为病例组,30例无感染的黄疸患儿作为对照组,分别检测两组患儿血清中的hs-CRP、肌钙蛋白-I水平。结果 HIE患儿与对照组;重度组与中度组;重度组与轻度组;中度组与轻度组比较hs-CRP和cTnI均明显增高(P<0.05)。结论 HIE患儿hs-CRP和cTnI升高且与HIE的严重程度呈正相关,能较敏感的反映HIE患儿病情程度,可以作为HIE严重程度的临床监测指标之一。
Objective To investigate the relationship between serum hs-CRP, cTnI and severity of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Sixty children with HIE were selected as the case group and 30 children without jaundice as the control group. Serum hs-CRP and troponin-I levels were measured in two groups. Results The levels of hs-CRP and cTnI in children with HIE were significantly higher than those in control group, severe and moderate group, severe and mild group, and moderate and mild group respectively (P <0.05). Conclusion The levels of hs-CRP and cTnI in children with HIE are positively correlated with the severity of HIE, which can reflect the severity of HIE and can be used as one of the clinical indicators of HIE severity.