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目的本研究拟通过荟萃分析评价脂联素基因(ADIPOQ)三个多态位点,包括rs2241766、rs1501299和rs266729与脑卒中和高血压的相关性。方法通过文献检索,收集国内外相关研究文献,应用固定效应模型和随机效应模型两种方法合并比值比(OR)及相应的95%置信区间(95%CI),同时检验研究间的异质性。结果本项荟萃分析共纳入16项研究,其中脑卒中荟萃分析纳入1,586个病例和5,426个对照;高血压荟萃分析纳入1,751个病例和3,025个对照。rs2241766和rs266729与脑卒中存在显著关联。固定效应模型合并OR值(95%CI;P值)分别为1.28(95%CI:1.12,1.46;P<0.0001)和1.20(95%CI:1.08,1.34;P=0.0001)。在rs2241766与脑卒中的荟萃分析中发现纳入的研究间存在显著异质性(I2=70%,P=0.01),应用随机效应模型合并OR值为1.26(95%CI:0.98,1.63;P=0.07)。三个位点与高血压之间关联都没有统计学意义。结论本研究结果提示ADIPOQ基因单核苷酸多态性rs2241766和rs266729与脑卒中之间存在显著关联。
Objective This study was designed to evaluate the association of adiponectin gene (ADIPOQ) with three polymorphic loci, including rs2241766, rs1501299 and rs266729, with stroke and hypertension by meta-analysis. Methods Literature retrieval was used to collect relevant literatures at home and abroad. The OR and 95% confidence intervals (95% CI) were compared using the fixed effect model and the random effect model. The heterogeneity among the studies . Results A total of 16 studies were included in this meta-analysis, of which 1,586 were included in the stroke meta-analysis and 5,426 controls were included in the meta-analysis; 1,751 were included in the meta-analysis of hypertension and 3,025 controls were included in the meta-analysis. rs2241766 and rs266729 were significantly associated with stroke. The pooled OR (95% CI; P value) for the fixed effect model was 1.28 (95% CI: 1.12, 1.46; P <0.0001) and 1.20 (95% CI: 1.08, 1.34; P = 0.0001), respectively. A statistically significant heterogeneity was found in the meta-analyzes of rs2241766 and stroke (I2 = 70%, P = 0.01), with a randomized OR of 1.26 (95% CI: 0.98, 1.63; P = 0.07). The association between the three sites and hypertension was not statistically significant. Conclusion The results of this study suggest that ADIPOQ gene SNPs rs2241766 and rs266729 are significantly associated with stroke.