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细胞外基质(ECM)合成和降解代谢平衡的调节,特别是基质金属蛋白酶(MMPs)和金属蛋白酶组织抑制因子(TIMPs)两大酶系统的表达、调控及其功能与肺间质弥漫性纤维化之间的关系近来受到了广泛的研究及重视。本文就MMPs的分类及结构特点、活性调节及其特异性抑制物;尤其是MMPs与肺间质弥漫纤维化之间的关系及研究最新进展加以综述。
Regulation of extracellular matrix (ECM) synthesis and metabolic balance, especially the expression, regulation and function of the two major enzyme systems of matrix metalloproteinases (MMPs) and metalloproteinase tissue inhibitors (TIMPs) and interstitial diffuse fibrosis The relationship between has recently been extensively studied and valued. In this paper, the classification and structural features of MMPs, activity regulation and specific inhibitors; especially the relationship between MMPs and pulmonary interstitial fibrosis and the latest research progress are reviewed.