目的探讨脂联素检测在女性RA患者中的应用价值.方法采用酶联免疫吸附(ELISA)法分别对59例女性类风湿关节炎(rheumatoid arthritis,RA)患者、30例其他风湿病组、30例对照组血清脂联素进行检测.同时检测抗环瓜氨酸肽(CCP)抗体、CRP、IL-6、RF、ESR、DAS28积分;比较脂联素与它们之间的相关关系.结果女性 RA 患者血清脂联素水平(16.3±3.1μg/mL)明显高于其他风湿病组及正常对照组(P<0.01);RA 组脂联素与 DAS28、IL-6、CRP 相关(r=0.537、0.525、0.493,P 均0.05).结论脂联素检测在女性 RA 患者中有临床应用价值,脂联素(adiponectin,AD)参与了 RA 的慢性炎症过程.进一步深入研究脂联素在 RA 病理过程中的意义,将有助于进一步阐明 RA 发病机制、为 RA 寻找治疗与干预新靶标.“,”Objective: To explore the application value of the detection of adiponectin in female patients with rheumatoid arthritis. Methods: ELISA method was applied to detect the adiponectin in 59 female patients with RA, 30 others rheumatoid diseases and 30 normal controls. Moreover, the CCP antibody, CRP, IL-6, RF, ESR and DAS28 integral were also detected simultaneously. The correlationship between adiponectin and the above factors was analyzed. Results: Compared with other rheumatic diseases patients and normal controls, the adiponectin levels increased significantly in RA(16.3±3.1μg/mL, P<0.01). The adiponectin levels in RA is correlated with DAS28, IL-6 and CRP(r= 0.537、0.525、0.493, P0.05). Conclusion: The determination of adiponectin has clinical significance and AD participated in the chronic inflammatory process of RA. Further investigation about the importance of adiponectin in pathological mechanism wil help to further elucidate the pathogenesis of RA and to find a new targets for therapy and intervention of RA.