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目的探讨碱性成纤维细胞因子(bFGF)在外阴癌中的表达及意义。方法采用SABC免疫组织化学方法,检测bFGF的表达,其中外阴正常皮肤10例,VSCC(外阴鳞状细胞癌)30例。汇集VSCC患者的临床病理资料进行统计学分析。结果 bFGF在外阴正常皮肤、外阴鳞癌中表达差异有统计学意义(P<0.05)。结论碱性成纤维细胞因子bFGF与外阴癌的临床分期、病理分级、淋巴结转移及外阴癌的恶性进展有关。
Objective To investigate the expression and significance of basic fibroblast growth factor (bFGF) in vulvar cancer. Methods SABC immunohistochemistry was used to detect the expression of bFGF, including 10 normal vulvar skin and 30 vulvar squamous cell carcinoma (VSCC). Collect clinical and pathological data of VSCC patients for statistical analysis. Results The expression of bFGF in vulvar normal skin and vulvar squamous cell carcinoma was significantly different (P <0.05). Conclusion The basic fibroblast factor bFGF is associated with the clinical stage, histological grade, lymph node metastasis and the malignant progress of vulvar cancer.