31只大鼠行胸主动脉内皮剥脱术,随机分为对照组10只、雷公藤多甙组10只(9.4 mg/kg/d)和藻酸双酯钠组11只(30mg/kg/d).后两组于术前6天开始喂药.于术后14天观察各组大鼠胸主动脉新生内膜面积、内膜与中膜面积比、新生内膜覆盖率、~3H-TdR参入量.证明雷公藤多甙能显著抑制受损动脉内膜增生(P<0.001),而藻酸双酯钠则无此作用. Thirty-one rats were performed thoracic aortic endothelium stripping and randomly divided into control group (10), Tripterygium wilfordii group (10) (9.4 mg/kg/d) and alginate sodium (11%) (30 mg/kg/day). The latter two groups began to give medicine 6 days before surgery. At 14 days after surgery, the thoracic aorta neointimal area, intima-media area ratio, neointimal coverage, ~3H-TdR were observed in each group. The incorporation amount showed that Tripterygium wilfordii can significantly inhibit the intimal hyperplasia of damaged arteries (P<0.001), while sodium alginate did not.