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目的 探讨血管内皮细胞生长因子 (VEGF)的表达与子宫内膜癌临床病理参数和预后的关系 ,以及其与雌激素受体 (ER)和碱性成纤维细胞生长因子 (bFGF)表达之间的关系。方法 采用免疫组化SP法检测 6 6例子宫内膜癌和 19例正常子宫内膜的石蜡切片VEGF、ER和bFGF的表达。结果 子宫内膜癌VEGF的阳性表达率为 80 .3% ,其表达与组织学分级呈正相关 (r=0 .40 2 1,P <0 .0 1) ;ER表达与组织学分级呈负相关 (r=- 0 .2 45 5 ,P <0 .0 5 ) ;VEGF与bFGF的表达呈正相关 (r =0 .2 939,P <0 .0 5 )。ER阴性表达比ER阳性表达的患者预后差 (P <0 .0 5 )。ER表达与VEGF和bFGF的表达无显著相关性。结论 VEGF是子宫内膜癌重要的血管生成因子 ,ER表达与子宫内膜癌的预后有关 ,但与bFGF和VEGF的表达无关。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and the clinicopathological parameters and prognosis of endometrial carcinoma and its relationship with the expression of estrogen receptor (ER) and basic fibroblast growth factor (bFGF) relationship. Methods The expressions of VEGF, ER and bFGF in paraffin sections from 6 cases of endometrial carcinoma and 19 cases of normal endometrium were detected by immunohistochemical SP method. Results The positive expression rate of VEGF in endometrial carcinoma was 80.3%, which was positively correlated with the histological grade (r = 0.40 2 1, P <0.01). The expression of ER was negatively correlated with the histological grade (r = - 0.245, P <0.05). The expression of VEGF and bFGF was positively correlated (r = 0.2939, P <0.05). The prognosis of patients with ER negative expression was higher than that of ER positive expression (P <0.05). There was no significant correlation between ER expression and VEGF and bFGF expression. Conclusion VEGF is an important angiogenic factor of endometrial carcinoma. The expression of ER is related to the prognosis of endometrial carcinoma, but not to the expression of bFGF and VEGF.