论文部分内容阅读
自然杀伤(NK)细胞是固有免疫系统重要成员之一,人们对于NK细胞的认知主要源于在体内广泛分布的经典NK细胞的研究.肝脏作为天然免疫优势器官,含有数量丰富且具异质性的NK细胞.与经典NK相比,肝脏特有NK细胞具有独特表型特征和肝组织驻留特性,能介导接触性超敏反应,发育过程受不同的转录因子调控.该发现推动了对不同于经典NK细胞的、组织器官特异性NK细胞亚群的研究.本文简要综述了肝脏特有NK细胞的研究背景、发现过程、发育分化以及功能特征.
Natural killer (NK) cells are one of the most important members of the innate immune system and their cognition of NK cells is mainly derived from the study of classical NK cells widely distributed in the body. As a natural immune dominant organ, the liver contains abundant and heterogeneous Sexual NK cells.Compared with the classical NK, the liver-specific NK cells have unique phenotypic characteristics and liver tissue resident properties, which can mediate contact hypersensitivity and the development of which is regulated by different transcription factors. Different from the classic NK cells, tissue-specific NK cell subsets research.This paper briefly reviewed the background of the liver specific NK cells, found that the process of development and differentiation as well as functional characteristics.