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目的探讨新生儿重症监护病房(neonatal intensive care unit,NICU)中极低出生体重儿(extremely low birth weight infants,ELBWI)肠道外营养相关性胆汁淤积(parenteral nutrition-associated cholestasis,PNAC)的危险因素。方法回顾NICU中229例静脉营养支持两周以上的极低出生体重儿的临床资料,比较PNAC组与非PNAC组在胎龄、出生体重等临床资料的差异。结果极低出生体重儿PNAC发生率为11.79%(27/229),PNAC组患儿胎龄、出生体重小于非PNAC组,而PN持续时间、PN热卡摄入量、脂肪乳最大剂量及累计用量、感染、贫血发生率大于非PNAC组(P<0.05)。结论低胎龄、低出生体重、PN持续时间过长、PN提供热卡过高、脂肪乳最大剂量及累计用量、感染、贫血是极低出生体重儿发生PNAC的危险因素。
Objective To investigate the risk factors of parenteral nutrition-associated cholestasis (PNAC) in extremely low birth weight infants (ELBWI) in neonatal intensive care unit (NICU). Methods The clinical data of 229 infants with very low birth weight who were supported by intravenous nutrition for more than two weeks in the NICU were retrospectively analyzed. The differences in gestational age, birth weight and other clinical data between PNAC group and non-PNAC group were compared. Results The incidence of PNAC in very low birth weight children was 11.79% (27/229). The gestational age and birth weight in PNAC group were less than those in non-PNAC group, while PN duration, PN calorie intake, maximum fat emulsion dosage and cumulative The incidence of infection, anemia was higher than that of non-PNAC group (P <0.05). CONCLUSIONS: Low gestational age, low birth weight, prolonged PN duration, excessive heat card provided by PN, maximum dosage and cumulative dose of fat emulsion, infection and anemia are risk factors for PNAC in very low birth weight infants.