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在巴西等地已取得使用埋藏避孕药的临床经验。八年来对几种用作植入剂的化合物之作用进行了筛选,要求达到剂量低、避孕效果好、无雌素和雄素副作用,能连续缓慢地从胶囊中释放,以达到长效作用。同时放弃了一些由于释放过快如氯地孕酮醋酸盐,或引起埋藏部位炎症的药物如孕激素ST-1572等。本文试用8种化合物,并作了临床估价。作者取材于4,752例孕龄妇女,所用药物为三烯炔诺酮(R 2010)、甲基三烯炔诺酮(R 2323)、醋酸甲地孕酮(MA)、18甲基炔诺酮(d-Ng)、
In Brazil and other places have made use of buried contraceptive clinical experience. In the past eight years, several compounds that act as implants have been screened for their low dosage, good contraceptive effects, no estrogen and feminine side effects, and sustained and slow release from the capsules for long-lasting effects. At the same time give up because of the release of too fast, such as chlormadinone acetate, or cause inflammation of the buried parts of the drug such as progesterone ST-1572 and so on. This article tried eight compounds, and made a clinical evaluation. The authors drew on 4,752 women of gestational age who used norepinephrine (R 2010), norepinephrine (R 2323), megestrol acetate (MA), norepinephrine 18 d-Ng),